Circulation:动脉钙化与瓣膜钙化的EVs多组学揭示特异调控因子
通过全组织蛋白质组学和组织EV囊泡组学,研究发现动脉钙化和瓣膜钙化具有不同的驱动因素。进一步分析揭示了颈动脉斑块和AV钙化组织中的关键蛋白,涉及细胞粘附、迁移、炎症、补体级联反应等途径...
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling (Cell Reports IF=9.4)
'single-cell RNA seq','干细胞与转分化'。参与CAVD疾病驱动VICs亚群DDP-VICs(CD44^high^CD29^+^CD59^+^CD73^+^CD45^low^) 总结  作者通过高通量流式检测鉴定出一个参与CAVD疾病驱动VICs...
Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field
Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field Article type: Review Files: CIRCRESAHA.116.310060.pdf Publication Year: 201...












