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A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling (Cell Reports IF=9.4)
'single-cell RNA seq','干细胞与转分化'。参与CAVD疾病驱动VICs亚群DDP-VICs(CD44^high^CD29^+^CD59^+^CD73^+^CD45^low^) 总结 作者通过高通量流式检测鉴定出一个参与CAVD疾病驱动VICs...
Resistin: Potential biomarker and therapeutic target in atherosclerosis
Zhou, Li, Jun-Yi Li, Ping-Ping He, Xiao-Hua Yu, and Chao-Ke Tang. “Resistin: Potential Biomarker and Therapeutic Target in Atherosclerosis.” Clinica Chimica Acta; International J...
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity
主要研究结果 SORT1与AS的遗传关联 对SORT1基因组50kb范围的555个变体进行meta分析: 11个变体与AS显著相关,但可能仅包含一个独立的信号 sortlin缺失减弱主动脉瓣狭窄的发展并...